RT Journal Article
T1 Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?
T2 Influencia de la infección SARS-CoV-2 sobre enfermedades neurodegenerativas y neuropsiquiátricas: ¿una pandemia demorada?
A1 Serrano-Castro, P J
A1 Estivill-Torrús, G
A1 Cabezudo-García, P
A1 Reyes-Bueno, J A
A1 Ciano Petersen, N
A1 Aguilar-Castillo, M J
A1 Suárez-Pérez, J
A1 Jiménez-Hernández, M D
A1 Moya-Molina, M Á
A1 Oliver-Martos, B
A1 Arrabal-Gómez, C
A1 Rodríguez de Fonseca, F
K1 COVID-19
K1 Cytokine storm
K1 Enfermedades neurodegenerativas
K1 Enfermedades neuropsiquiátricas
K1 Neurodegenerative diseases
K1 Neuroinflamación
K1 Neuroinflammation
K1 Neuropsychiatric diseases
K1 SARS-CoV-2
K1 Tormenta de citoquinas
AB SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.
YR 2020
FD 2020-04-17
LK https://hdl.handle.net/10668/24587
UL https://hdl.handle.net/10668/24587
LA en
LA es
DS RISalud
RD Apr 8, 2025