RT Journal Article
T1 Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study.
A1 Bodro, Marta
A1 Cervera, Carlos
A1 Linares, Laura
A1 Suarez, Belen
A1 Llopis, Jaume
A1 Sanclemente, Gemma
A1 Casado-Llombart, Sergi
A1 Fernandez-Ruiz, Mario
A1 Fariñas, Maria Carmen
A1 Cantisan, Sara
A1 Montejo, Miguel
A1 Cordero, Elisa
A1 Oriol, Isabel
A1 Marcos, Maria Angeles
A1 Lozano, Francisco
A1 Moreno, Asuncion
K1 cytomegalovirus
K1 infectious disease
K1 innate immunity
K1 multicenter study
K1 solid organ transplantation
AB Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9, AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/recipient mismatch (D+/R-) transplant recipients.
PB Frontiers Research Foundation
YR 2022
FD 2022-08-09
LK http://hdl.handle.net/10668/20588
UL http://hdl.handle.net/10668/20588
LA en
NO Bodro M, Cervera C, Linares L, Suárez B, Llopis J, Sanclemente G, et al. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study. Front Immunol. 2022 Aug 9;13:897912.
DS RISalud
RD Jul 1, 2025