RT Generic T1 The Essentials of Marine Biotechnology A1 Rotter, Ana A1 Barbier, Michele A1 Bertoni, Francesco A1 Bones, Atle M. A1 Cancela, M. Leonor A1 Carlsson, Jens A1 Carvalho, Maria F. A1 Ceglowska, Marta A1 Chirivella-Martorell, Jeronimo A1 Dalay, Meltem Conk A1 Cueto, Mercedes A1 Dailianis, Thanos A1 Deniz, Irem A1 Diaz-Marrero, Ana R. A1 Drakulovic, Dragana A1 Dubnika, Arita A1 Edwards, Christine A1 Einarsson, Hjoerleifur A1 Erdogan, Aysegul A1 Eroldogan, Orhan Tufan A1 Ezra, David A1 Fazi, Stefano A1 FitzGerald, Richard J. A1 Gargan, Laura M. A1 Gaudencio, Susana P. A1 Udovic, Marija Gligora A1 DeNardis, Nadica Ivosevic A1 Jonsdottir, Rosa A1 Katarzyte, Marija A1 Klun, Katja A1 Kotta, Jonne A1 Ktari, Leila A1 Ljubesic, Zrinka A1 Bilela, Lada Lukic A1 Mandalakis, Manolis A1 Massa-Gallucci, Alexia A1 Matijosyte, Inga A1 Mazur-Marzec, Hanna A1 Mehiri, Mohamed A1 Nielsen, Soren Laurentius A1 Novoveska, Lucie A1 Overlinge, Donata A1 Perale, Giuseppe A1 Ramasamy, Praveen A1 Rebours, Celine A1 Reinsch, Thorsten A1 Reyes, Fernando A1 Rinkevich, Baruch A1 Robbens, Johan A1 Roettinger, Eric A1 Rudovica, Vita A1 Sabotid, Jerica A1 Safarik, Ivo A1 Talve, Siret A1 Tasdemir, Deniz A1 Schneider, Xenia Theodotou A1 Thomas, Olivier P. A1 Torunska-Sitarz, Anna A1 Varese, Giovanna Cristina A1 Vasquez, Marlen, I K1 bioprospecting K1 blue growth K1 marine biodiversity K1 marine natural products K1 sustainability K1 ethics K1 responsible research and innovation (RRI) K1 marine bioeconomy K1 Solid-phase microextraction K1 Particulate organic-carbon K1 Heavy-metal detoxification K1 Waste-water treatment K1 In-silico prediction K1 Lead-like molecules K1 Deep-sea sediments K1 Natural-products K1 Bioactive compounds K1 Secondary metabolites AB Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech - European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs. PB Frontiers media sa YR 2021 FD 2021-03-16 LK http://hdl.handle.net/10668/19222 UL http://hdl.handle.net/10668/19222 LA en DS RISalud RD Apr 11, 2025