RT Journal Article
T1 Genetic variation associated with cardiovascular risk in autoimmune diseases.
A1 Perrotti, Pedro P
A1 Aterido, Adria
A1 Fernandez-Nebro, Antonio
A1 Cañete, Juan D
A1 Ferrandiz, Carlos
A1 Tornero, Jesus
A1 Gisbert, Javier P
A1 Domenech, Eugeni
A1 Fernandez-Gutierrez, Benjamin
A1 Gomollon, Fernando
A1 Garcia-Planella, Esther
A1 Fernandez, Emilia
A1 Sanmarti, Raimon
A1 Gratacos, Jordi
A1 Martinez-Taboada, Victor Manuel
A1 Rodriguez-Rodriguez, Luis
A1 Palau, Nuria
A1 Tortosa, Raul
A1 Corbeto, Mireia L
A1 Lasanta, Maria L
A1 Marsal, Sara
A1 Julia, Antonio
K1 Autoimmune Diseases
K1 Genome
K1 Autoimmunity
K1 Cardiovascular Diseases
K1 Genetic Variation
AB Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. We analyzed genome-wide genotyping data from 6,485 patients from six autoimmune diseases that are associated with a high socio-economic impact. First, for each disease, we tested the association of established CVD risk loci. Second, we analyzed the association of autoimmune disease susceptibility loci with CVD. Finally, to identify genetic patterns associated with CVD risk, we applied the cross-phenotype meta-analysis approach (CPMA) on the genome-wide data. A total of 17 established CVD risk loci were significantly associated with CVD in the autoimmune patient cohorts. From these, four loci were found to have significantly different genetic effects across autoimmune diseases. Six autoimmune susceptibility loci were also found to be associated with CVD risk. Genome-wide CPMA analysis identified 10 genetic clusters strongly associated with CVD risk across all autoimmune diseases. Two of these clusters are highly enriched in pathways previously associated with autoimmune disease etiology (TNFα and IFNγ cytokine pathways). The results of this study support the presence of specific genetic variation associated with the increase of CVD risk observed in autoimmunity.
PB Public Library of Science
YR 2017
FD 2017-10-05
LK http://hdl.handle.net/10668/11650
UL http://hdl.handle.net/10668/11650
LA en
NO Perrotti PP, Aterido A, Fernández-Nebro A, Cañete JD, Ferrándiz C, Tornero J, et al. Genetic variation associated with cardiovascular risk in autoimmune diseases. PLoS One. 2017 Oct 5;12(10):e0185889
DS RISalud
RD Apr 12, 2025