RT Journal Article
T1 Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study.
A1 Muralidharan, Jananee
A1 Moreno-Indias, Isabel
A1 Bulló, Mónica
A1 Lopez, Jesús Vioque
A1 Corella, Dolores
A1 Castañer, Olga
A1 Vidal, Josep
A1 Atzeni, Alessandro
A1 Fernandez-García, Jose Carlos
A1 Torres-Collado, Laura
A1 Fernández-Carrión, Rebeca
A1 Fito, Monsterrat
A1 Olbeyra, Romina
A1 Gomez-Perez, Ana Maria
A1 Galiè, Serena
A1 Bernal-López, Maria Rosa
A1 Martinez-Gonzalez, Miguel Angel
A1 Salas-Salvadó, Jordi
A1 Tinahones, Francisco Jose
K1 Mediterranean diet
K1 energy restriction
K1 gut microbiota
K1 obesity
K1 weight loss
AB The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors. To investigate the effect of an intensive lifestyle weight loss intervention on gut microbiota. This is a substudy of the PREDIMED-Plus (Prevención con Dieta Mediterránea-Plus), a randomized controlled trial conducted in overweight/obese men and women (aged 55-75 y) with metabolic syndrome. The intervention group (IG) underwent an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet) and physical activity promotion, and the control group (CG) underwent a non-energy-restricted MedDiet for 1 y. Anthropometric, biochemical, and gut microbial 16S rRNA sequencing data were analyzed at baseline (n = 362) and 1-y follow-up (n = 343). IG participants had a weight loss of 4.2 (IQR, -6.8, -2.5) kg compared with 0.2 (IQR, -2.1, 1.4) kg in the CG (P  Weight loss induced by an energy-restricted MedDiet and physical activity induce changes in gut microbiota. The role of MedDiet-induced changes on the host might be via short-chain fatty acid producing bacteria, whereas with energy restriction, these changes might be modulated with other mechanisms, which need to be explored in future studies. This trial was registered at http://www.isrctn.com/ISRCTN89898870 as ISRCT 89898870.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/27005
UL https://hdl.handle.net/10668/27005
LA en
DS RISalud
RD Apr 7, 2025