RT Journal Article
T1 Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.
A1 Nerpin, Elisabet
A1 Ferreira, Diogenes Seraphim
A1 Weyler, Joost
A1 Schlunnsen, Vivi
A1 Jogi, Rain
A1 Raherison Semjen, Chantal
A1 Gislasson, Thorainn
A1 Demoly, Pascal
A1 Heinrich, Joachim
A1 Nowak, Dennis
A1 Corsico, Angelo
A1 Accordini, Simone
A1 Marcon, Alessandro
A1 Squillacioti, Giulia
A1 Olivieri, Mario
A1 Nielsen, Rune
A1 Johannessen, Ane
A1 Gómez Real, Francisco
A1 Garcia-Aymerich, Judith
A1 Urrutia, Isabel
A1 Pereira-Vega, Antonio
A1 Gullón, Jose Antonio
A1 Olin, Anna-Carin
A1 Forsberg, Bertil
A1 Emilsson, Össur Ingi
A1 Pin, Isabelle
A1 Jarvis, Deborah
A1 Janson, Christer
A1 Malinovschi, Andrei
K1 Bronchodilatation
K1 Epidemiology
K1 FeNO
K1 Lung function
AB Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. Among asthmatic subjects, higher percentage declines of FEV1 and FEV1/FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses.Percentage increase in FEV1 after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV1 and FeNO levels in non-smokers and women, regardless of asthma status. We found a relationship between elevated FeNO and larger FEV1 decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.
SN 1939-4551
YR 2021
FD 2021-05-18
LK http://hdl.handle.net/10668/17966
UL http://hdl.handle.net/10668/17966
LA en
DS RISalud
RD Apr 19, 2025