TY  - JOUR
AU  - Silva, Sonia
AU  - Camino, Lola P
AU  - Aguilera, Andrés
PY  - 2018
DO  - 10.1073/pnas.1807258115
UR  - http://hdl.handle.net/10668/13052
T2  - Proceedings of the National Academy of Sciences of the United States of America
AB  - R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become...
LA  - en
KW  - R loops
KW  - RNA metabolism
KW  - genome instability
KW  - mitochondrial degradosome
KW  - transcription–replication conflicts
KW  - Cell Line, Tumor
KW  - DEAD-box RNA Helicases
KW  - DNA, Mitochondrial
KW  - DNA, Single-Stranded
KW  - Endoribonucleases
KW  - Exosome Multienzyme Ribonuclease Complex
KW  - Genome, Mitochondrial
KW  - Genomic Instability
KW  - HeLa Cells
KW  - Humans
KW  - Mitochondria
KW  - Multienzyme Complexes
KW  - Polyribonucleotide Nucleotidyltransferase
KW  - RNA Helicases
KW  - RNA Stability
KW  - RNA, Double-Stranded
KW  - Ribonucleases
TI  - Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
TY  - research article
VL  - 115
ER  -