RT Journal Article
T1 Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children.
A1 Ordóñez-Díaz, Maria D
A1 Pérez-Navero, Juan L
A1 Flores-Rojas, Katherine
A1 Olza-Meneses, Josune
A1 Muñoz-Villanueva, Maria C
A1 Aguilera-García, Concepción M
A1 Gil-Campos, Mercedes
K1 cytokines
K1 extrauterine growth restriction
K1 hypertension
K1 inflammation
K1 metabolism
K1 prematurity
K1 programming
AB Introduction: An adipose tissue programming mechanism could be implicated in the extrauterine growth restriction (EUGR) of very preterm infants with morbidity in the cardiometabolic status later in life, as has been reported in intrauterine growth restriction. The aim of this study was to assess whether children with a history of prematurity and EUGR, but also with an adequate growth, showed alterations in the metabolic and inflammatory status. Methods: This was a case-control study. A total of 88 prepubertal children with prematurity antecedents were selected: 38 with EUGR and 50 with an adequate growth pattern (PREM group). They were compared with 123 healthy children born at term. Anthropometry, metabolic parameters, blood pressure (BP), C-reactive protein, hepatocyte growth factor (HGF), interleukin-6 (IL-6), IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, tumour necrosis factor-alpha (TNF-α) and plasminogen activator inhibitor type-1 were analysed at the prepubertal age. Results: EUGR children exhibited higher BP levels and a higher prevalence of hypertension (46%) compared with both PREM (10%) and control (2.5%) groups. Moreover, there was a positive relationship between BP levels and values for glucose, insulin and HOMA-IR only in children with a EUGR history. The EUGR group showed higher concentrations of most of the cytokines analysed, markedly higher TNF-α, HGF and MCP-1 levels compared with the other two groups. Conclusion: EUGR status leads to cardiometabolic changes and a low-grade inflammatory status in children with a history of prematurity, and that could be related with cardiovascular risk later in life.
SN 2296-2360
YR 2020
FD 2020-04-21
LK https://hdl.handle.net/10668/25483
UL https://hdl.handle.net/10668/25483
LA en
DS RISalud
RD Apr 12, 2025