RT Journal Article
T1 Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic patients.
A1 Giner, Mercè
A1 Montoya, Mª José
A1 Vázquez, Mª Angeles
A1 Miranda, Cristina
A1 Pérez-Cano, Ramón
K1 Human bone
K1 Osteoporosis
K1 Osteogenesis
K1 Apoptosis
K1 Microstructural
K1 Densidad Ósea
K1 Fracturas de cadera
K1 Ancianos de 80 o más años
K1 Reacción en cadena de la polimerasa en tiempo real
K1 Reacción en cadena de la polimerasa por transcriptasa inversa
AB BACKGROUNDOsteoporosis is a metabolic disorder characterized by a reduction in bone mass and deterioration in the microarchitectural structure of the bone, leading to a higher risk for spontaneous and fragility fractures.The main aim was to study the differences between human bone from osteoporotic and osteoarthritic patients about gene expression (osteogenesis and apoptosis), bone mineral density, microstructural and biomechanic parameters.METHODSWe analyzed data from 12 subjects: 6 with osteoporotic hip fracture (OP) and 6 with hip osteoarthritis (OA), as the control group. All subjects underwent medical history, analytical determinations, densitometry, histomorphometric and biochemical study. The expression of 86 genes of osteogenesis and 86 genes of apoptosis was studied in pool of bone samples from patients with OP and OA by PCR array.RESULTSWe observed that most of the genes of apoptosis and osteogenesis show a decrease in gene expression in the osteoporotic group in comparison with the osteoarthritic group. The histomorphometric study shows a lower bone quality in the group of patients with hip fractures compared to the osteoarthritic group.CONCLUSIONSThe bone tissue of osteoporotic fracture patients is more fragile than the bone of OA patients. Our results showed an osteoporotic bone with a lower capacities for differentiation and osteoblastic activity as well as a lower rate of apoptosis than osteoarthritic bone. These results are related with structural and biochemical parameters.
PB BioMed Central
YR 2013
FD 2013-01-25
LK http://hdl.handle.net/10668/1304
UL http://hdl.handle.net/10668/1304
LA en
NO Giner M, Montoya MJ, Vázquez MA, Miranda C, Pérez-Cano R. Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic patients. BMC Musculoskelet Disord.2013 Jan 25; 14:41
NO Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025