%0 Journal Article
%A Pérez-Ruiz, Elisabeth
%A Etxeberria, Iñaki
%A Rodriguez-Ruiz, Maria E
%A Melero, Ignacio
%T Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy.
%D 2017
%U https://hdl.handle.net/10668/26705
%X T-cell costimulation and coinhibition can be respectively exploited by blocking and agonist mAbs. Both strategies can be synergistically combined in mouse models. Early clinical results from combinations of anti-PD-1 mAbs in conjunction with agonist anti-CD137 (4-1BB) mAbs show excellent safety and promising efficacy. Clin Cancer Res; 23(18); 5326-8. ©2017 AACRSee related article by Tolcher et al., p. 5349.
%~