RT Journal Article
T1 Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population
A1 Narankiewicz, Dariusz
A1 Ruiz-Nava, Josefina
A1 Buonaiuto, Veronica
A1 Ruiz-Moreno, María Isabel
A1 López-Carmona, María Dolores
A1 Pérez-Belmonte, Luis Miguel
A1 Gómez-Huelgas, Ricardo
A1 Bernal-López, María Rosa
K1 Non-alcoholic fatty liver disease
K1 Body mass index
K1 Lipids
K1 Diabetes
K1 Liver function tests
K1 Andalusian
K1 Enfermedad del hígado graso no alcohólico
K1 Índice de masa corporal
K1 Lípidos
K1 Pruebas de función hepática
K1 Andalucía
AB The aim of this study was to analyze the utility of liver function tests (LFT) and fatty liver index (FLI), a surrogate marker of non-alcoholic fatty liver disease, in the categorization of metabolic phenotypes in a Mediterranean population. A cross-sectional study was performed on a random representative sample of 2233 adults assigned to a health center in Málaga, Spain. The metabolic phenotypes were determined based on body mass index (BMI) categorization and the presence or absence of two or more cardiometabolic abnormalities (high blood pressure, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, pre-diabetes) or type 2 diabetes. No difference was observed between metabolically healthy and metabolically abnormal phenotypes on LFT. The mean FLI of the population was 41.1 ± 28.6. FLI was significantly higher (p < 0.001) in the metabolically abnormal phenotypes in all BMI categories. The proportion of individuals with pathological FLI (≥60) was significantly higher in the metabolically abnormal overweight and obese phenotypes (p < 0.001). On a multivariate model adjusted for sex, age, and waist circumference, a significant correlation was found between pathological FLI and metabolically abnormal phenotypes in the overweight and obese BMI categories. Area under the curve (AUC) of FLI as a biomarker was 0.76, 0.74, and 0.72 for the metabolically abnormal normal-weight, overweight, and obese groups, respectively. Liver biochemistry is poorly correlated with metabolic phenotypes. Conversely, a good correlation between FLI, as a marker of non-alcoholic fatty liver disease (NAFLD), and metabolically abnormal phenotypes in all BMI ranges was found. Our study suggests that FLI may be a useful marker for characterizing metabolically abnormal phenotypes in individuals who are overweight or obese.
PB MDPI
SN 1661-7827
YR 2020
FD 2020-05-18
LK http://hdl.handle.net/10668/4249
UL http://hdl.handle.net/10668/4249
LA en
NO Narankiewicz D, Ruiz-Nava J, Buonaiuto V, Ruiz-Moreno MI, López-Carmona MD, Pérez-Belmonte LM, et al. Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population. Int J Environ Res Public Health. 2020 May 18;17(10):3518
DS RISalud
RD Apr 7, 2025