RT Journal Article
T1 A New Data Analysis System to Quantify Associations between Biochemical Parameters of Chronic Kidney Disease-Mineral Bone Disease.
A1 Rodriguez, Mariano
A1 Salmeron, M Dolores
A1 Martin-Malo, Alejandro
A1 Barbieri, Carlo
A1 Mari, Flavio
A1 Molina, Rafael I
A1 Costa, Pedro
A1 Aljama, Pedro
K1 Renal dialysis
K1 Renal insufficiency, chronic
K1 Statistics as topic
K1 Aged
AB In hemodialysis patients, deviations from KDIGO recommended values of individual parameters, phosphate, calcium or parathyroid hormone (PTH), are associated with increased mortality. However, it is widely accepted that these parameters are not regulated independently of each other and that therapy aimed to correct one parameter often modifies the others. The aim of the present study is to quantify the degree of association between parameters of chronic kidney disease and mineral bone disease (CKD-MBD). Data was extracted from a cohort of 1758 adult HD patients between January 2000 and June 2013 obtaining a total of 46.141 records (10 year follow-up). We used an advanced data analysis system called Random Forest (RF) which is based on self-learning procedure with similar axioms to those utilized for the development of artificial intelligence. This new approach is particularly useful when the variables analyzed are closely dependent to each other. The analysis revealed a strong association between PTH and phosphate that was superior to that of PTH and Calcium. The classical linear regression analysis between PTH and phosphate shows a correlation coefficient is 0.27, p Our results suggest that the analysis of the complex interactions between mineral metabolism parameters in CKD-MBD may demand a more advanced data analysis system such as RF.
PB Public Library of Science
YR 2015
FD 2015-12-21
LK http://hdl.handle.net/10668/9768
UL http://hdl.handle.net/10668/9768
LA en
NO Rodriguez M, Salmeron MD, Martin-Malo A, Barbieri C, Mari F, Molina RI, et al. A New Data Analysis System to Quantify Associations between Biochemical Parameters of Chronic Kidney Disease-Mineral Bone Disease. PLoS One. 2016 Jan 25;11(1):e0146801
DS RISalud
RD Apr 11, 2025