RT Journal Article
T1 Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study.
A1 Jiménez-Jorge, Silvia
A1 Palacios-Baena, Zaira R
A1 Rosso-Fernández, Clara M
A1 Girón-Ortega, José A
A1 Rodriguez-Baño, Jesús
A1 Retamar, Pilar
K1 antibiotic prescribing
K1 antimicrobial stewardship programs
K1 cluster randomised controlled trial
K1 negative blood culture
AB Patients with negative blood cultures (BCx) represent 85%-90% of all patients with BCx taken during hospital admission. This population usually includes a heterogeneous group of patients admitted with infectious diseases or febrile syndromes that require a blood culture. There is very little evidence of the clinical characteristics and antibiotic treatment given to these patients. In a preliminary exploratory prospective cohort study of patients with BCx taken, the clinical/therapeutic characteristics and outcomes/antimicrobial stewardship opportunities of a population of patients with negative BCx will be analysed. In the second phase, using a cluster randomised crossover design, the implementation of an antimicrobial stewardship intervention targeting patients with negative BCx will be evaluated in terms of quality of antimicrobial use (duration and de-escalation), length of hospital stay and mortality. This study has been and registered with clinicaltrials.gov. The findings of our study may support the implementation in clinical practice of an antimicrobial stewardship intervention to optimise the use of antibiotics in patients with negative BCx. The results of this study will be published in peer-reviewed journals and disseminated at national and international conferences. NCT03535324.
YR 2019
FD 2019-12-18
LK http://hdl.handle.net/10668/14851
UL http://hdl.handle.net/10668/14851
LA en
DS RISalud
RD Apr 9, 2025