TY  - JOUR
AU  - Safari, Maryam
AU  - Litman, Thomas
AU  - Robey, Robert W
AU  - Aguilera, Andrés
AU  - Chakraborty, Arup R
AU  - Reinhold, William C
AU  - Basseville, Agnes
AU  - Petrukhin, Lubov
AU  - Scotto, Luigi
AU  - O'Connor, Owen A
AU  - Pommier, Yves
AU  - Fojo, Antonio T
AU  - Bates, Susan E
PY  - 2021
DO  - 10.1158/1541-7786.MCR-20-0833
UR  - http://hdl.handle.net/10668/17849
T2  - Molecular cancer research : MCR
AB  - Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite regulatory approvals in hematological malignancies, limited solid tumor clinical activity has constrained their potential, arguing for...
LA  - en
KW  - Acetylation
KW  - Cell Line, Tumor
KW  - DNA Damage
KW  - DNA Repair
KW  - DNA, Single-Stranded
KW  - Depsipeptides
KW  - Histone Deacetylase Inhibitors
KW  - Histone Deacetylases
KW  - Humans
KW  - PC-3 Cells
KW  - R-Loop Structures
TI  - R-Loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin.
TY  - research article
VL  - 19
ER  -