TY - JOUR AU - Alcalde-Estévez, Elena AU - Arroba, Ana I AU - Sánchez-Fernández, Elena M AU - Mellet, Carmen Ortiz AU - García Fernández, Jose M AU - Masgrau, Laura AU - Valverde, Ángela M PY - 2017 DO - 10.1016/j.fct.2017.11.050 UR - http://hdl.handle.net/10668/11861 T2 - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AB - Neuroinflammation is an early event during diabetic retinopathy (DR) that impacts the dynamics of microglia polarization. Gliosis is a hallmark of DR and we have reported the beneficial effects of 1R-DSO-ONJ, a member of the sp2-iminosugar glycolipid... LA - en KW - Diabetic retinopathy KW - Glycolipid KW - Heme oxygenase-1 KW - Inflammation KW - p38α MAPK KW - sp(2)-iminosugar KW - Animals KW - Anti-Inflammatory Agents KW - Cell Line KW - Gene Expression Regulation, Enzymologic KW - Glycolipids KW - Heme Oxygenase-1 KW - Lipopolysaccharides KW - Mice KW - Mice, Inbred NOD KW - Microglia KW - Retina KW - Tissue Culture Techniques TI - The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants. TY - research article VL - 111 ER -