RT Journal Article
T1 Role of gene methylation in antitumor immune response: Implication for tumor progression
A1 Serrano Garballo, Alfonso
A1 Castro Vega, Isabel
A1 Redondo, Maximino
K1 Enfermedades Gastrointestinales
K1 Neoplasias Hematológicas
K1 Línea Celular Tumoral
K1 Azacitidina
K1 5,6-Dihidroxitriptamina
K1 Proteínas Portadoras
K1 Inhibidor p16 de la Quinasa Dependiente de Ciclina
K1 ADN
K1 Metilasas de Modificación del ADN
K1 Inhibidores de Histona Desacetilasas
K1 Antígenos HLA
K1 Interleucina-10
K1 Antígeno MART-1
K1 Proteínas Quinasas Mitógeno Activadas
K1 Subfamilia K de Receptores Similares a Lectina de Células NK
K1 Proteínas ras
K1 Transportadoras de Casetes de Unión a ATP
K1 Ácidos Hidroxámicos
K1 Citidina
K1 Metilación de ADN
K1 Escape del Tumor
K1 Clusterina
AB Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response.
PB MDPI
YR 2011
FD 2011-07-18
LK http://hdl.handle.net/10668/742
UL http://hdl.handle.net/10668/742
LA en
NO Serrano Garballo A, Castro-Vega I, Redondo M. Role of gene methylation in antitumor immune response: Implication for tumor progression. Cancers. 2011;3(2):1672-1690
DS RISalud
RD Apr 14, 2025