%0 Journal Article
%A Serrano Garballo, Alfonso
%A Castro Vega, Isabel
%A Redondo, Maximino
%T Role of gene methylation in antitumor immune response: Implication for tumor progression
%D 2011
%U http://hdl.handle.net/10668/742
%X Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response.
%K Enfermedades Gastrointestinales
%K Neoplasias Hematológicas
%K Línea Celular Tumoral
%K Azacitidina
%K 5,6-Dihidroxitriptamina
%K Proteínas Portadoras
%K Inhibidor p16 de la Quinasa Dependiente de Ciclina
%K ADN
%K Metilasas de Modificación del ADN
%K Inhibidores de Histona Desacetilasas
%K Antígenos HLA
%K Interleucina-10
%K Antígeno MART-1
%K Proteínas Quinasas Mitógeno Activadas
%K Subfamilia K de Receptores Similares a Lectina de Células NK
%K Proteínas ras
%K Transportadoras de Casetes de Unión a ATP
%K Ácidos Hidroxámicos
%K Citidina
%K Metilación de ADN
%K Escape del Tumor
%K Clusterina
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