%0 Journal Article
%A Vicente-Pascual, Mikel
%A Rossi, Marcello
%A Gámez, Josep
%A Lladó, Albert
%A Valls, Josep
%A Grau-Rivera, Oriol
%A Ávila Polo, Rainiero
%A Llorens, Franc
%A Zerr, Inga
%A Ferrer, Isidre
%A Nos, Carlos
%A Parchi, Piero
%A Sánchez-Valle, Raquel
%A Gelpí, Ellen
%T Variably protease-sensitive prionopathy presenting within ALS/FTD spectrum.
%D 2018
%@ 2328-9503
%U http://hdl.handle.net/10668/13121
%X We report clinico-pathological features of a 65-year-old woman and a 56-year-old man with a 5-year clinical history who had clinical and neuropathological characteristics of upper and lower motor neuron disease consistent with amyotrophic lateral sclerosis, and a frontotemporal atrophy pattern in case 2 without TDP-43 pathology. Instead, spongiform change and pathological prion protein deposits were observed in several brain regions. No prion protein gene mutations were found. Western blot analysis showed a five-band profile compatible with variably protease-sensitive prionopathy. We conclude that this disease can display prolonged disease duration and clinico-pathological features within the ALS/FTLD spectrum.
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