TY - JOUR AU - López-Gómez, Carlos AU - Santiago-Fernández, Concepción AU - García-Serrano, Sara AU - García-Escobar, Eva AU - Gutiérrez-Repiso, Carolina AU - Rodríguez-Díaz, Cristina AU - Ho-Plágaro, Ailec AU - Martín-Reyes, Flores AU - Garrido-Sánchez, Lourdes AU - Valdés, Sergio AU - Rodríguez-Cañete, Alberto AU - Rodríguez-Pacheco, Francisca AU - García-Fuentes, Eduardo PY - 2020 DO - 10.3390/jcm9082615 UR - http://hdl.handle.net/10668/4103 T2 - Journal of Clinical Medicine AB - The effects of different types of fatty acids on the gene expression of key players in the IRS1/PI3K signaling pathway have been poorly studied. Material and Methods: We analyzed IRS1, p85α, and p110β mRNA expression and the fatty acid composition of... LA - en PB - MDPI KW - Morbid obesity KW - Insulin resistance KW - IRS1 KW - p85α KW - p110β KW - Palmitic acid KW - Oleic acid KW - Docosahexaenoic acid KW - Linoleic acid KW - Visceral adipose tissue KW - Obesidad mórbida KW - Resistencia a la insulina KW - Ácido palmítico KW - Ácido oléico KW - Ácidos docosahexaenoicos KW - Ácido linoleico KW - Grasa intraabdominal KW - Andalucía KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases KW - Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fat KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Morbid KW - Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Adipocytes KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Phospholipids KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Stearic Acids KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acids KW - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated KW - Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain TI - Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway TY - research article ER -