RT Journal Article
T1 Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study.
A1 Baumstarck, Karine
A1 Butzkueven, Helmut
A1 Fernández, Oscar
A1 Flachenecker, Peter
A1 Stecchi, Sergio
A1 Idiman, Egemen
A1 Pelletier, Jean
A1 Boucekine, Mohamed
A1 Auquier, Pascal
K1 Multiple sclerosis
K1 Quality of life
K1 Outcome research
K1 Responsiveness
K1 MusiQoL
K1 SF-36
K1 Longitudinal studies
K1 Esclerosis múltiple
K1 Calidad de Vida
K1 Estudios longitudinales
AB BACKGROUNDResponsiveness, defined as the ability to detect a meaningful change, is a core psychometric property of an instrument measuring quality of life (QoL) rarely reported in multiple sclerosis (MS) studies.OBJECTIVETo assess the responsiveness of the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire to change in disability over 24 months, defined by change in the Expanded Disability Status Scale (EDSS) score.METHODSPatients with MS were enrolled into a multicenter, longitudinal observational study. QoL was assessed using both the MusiQoL and the 36-Item Short-Form (SF-36) instruments at baseline and every 6 months thereafter up to month 24; neurological assessments, including EDSS score, were performed at each evaluation.RESULTSThe 24-month EDSS was available for 524 patients. In the 107 worsened patients, two specific dimensions of MusiQoL, the sentimental and sexual life and the relationships with health care system dimensions, and 'physical' scores of SF-36 showed responsiveness.CONCLUSIONSWhereas specific dimensions of MusiQoL identified EDSS changes, the MusiQoL index did not detect disability changes in worsened MS patients in a 24-month observational study. Future responsiveness validation studies should include longer follow-up and more representative samples.
PB BioMed Central
YR 2013
FD 2013-07-29
LK http://hdl.handle.net/10668/1435
UL http://hdl.handle.net/10668/1435
LA en
NO Baumstarck K, Butzkueven H, Fernández O, Flachenecker P, Stecchi S, Idiman E, et al. Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study. Health Qual Life Outcomes. 2013; 11(1):127
NO JOURNAL ARTICLE;
DS RISalud
RD Apr 11, 2025