RT Journal Article
T1 Alveolar overdistension as a cause of lung injury: differences among three animal species.
A1 García-Delgado, Manuel
A1 Navarrete-Sánchez, Inés
A1 Chamorro-Marín, Virginia
A1 Díaz-Monrové, Juan Carlos
A1 Esquivias, Javier
A1 Fernández-Mondéjar, Enrique
K1 Pulmón
K1 Lesión Pulmonar
K1 Neumotórax
K1 Respiración con Presión Positiva
K1 Alveolos Pulmonares
K1 Conejos
K1 Ratas
K1 Ratas Wistar
K1 Respiración Artificial
K1 Mecánica Respiratoria
K1 Especificidad de la Especie
K1 Porcinos
K1 Volumen de Ventilación Pulmonar
K1 Animales
AB This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species. Data were gathered on wet/dry weight ratio, histological score, and area of alveolar collapse. Five out of six rabbits with high tidal volume developed tension pneumothorax, and the rabbit results were therefore not included in the histological analysis. Lungs from the pigs and rats showed minimal histological lesions. Pigs ventilated with high tidal volume had significantly greater oedema, higher neutrophil infiltration, and higher percentage area of alveolar collapse than rats ventilated with high tidal volume. We conclude that rabbits are not an appropriate species for in vivo studies of alveolar overdistension due to their fragility. Although some histological lesions are observed in pigs and rats, the lesions do not appear to be relevant.
PB Scientific World
YR 2012
FD 2012
LK http://hdl.handle.net/10668/902
UL http://hdl.handle.net/10668/902
LA en
NO García-Delgado M, Navarrete-Sánchez I, Chamorro-Marín V, Díaz-Monrové JC, Esquivias J, Fernández-Mondéjar E. Alveolar overdistension as a cause of lung injury: differences among three animal species. ScientificWorldJournal; 2012:985923
NO Journal Article;
DS RISalud
RD Apr 10, 2025