RT Journal Article
T1 Influence of prognosis factors on the prescription of targeted treatments in rheumatoid arthritis: A Delphi survey.
A1 Narváez, Javier
A1 Otón, Teresa
A1 Calvo-Alén, Jaime
A1 Escudero-Contreras, Alejandro
A1 Muñoz-Fernández, Santiago
A1 Rodríguez-Heredia, José Manuel
A1 Romero-Yuste, Susana
A1 Vela-Casasempere, Paloma
A1 Luján, Sara
A1 Baquero, Jose Luis
A1 Carmona, Loreto
K1 Delphi
K1 Prognosis
K1 Rheumatoid arthritis
K1 Systematic review
AB To explore current evidence on the management of poor prognostic factors in rheumatoid arthritis (RA) and to investigate whether this evidence is taken into account by clinicians when deciding on treatment in daily clinical practice. We performed a systematic literature review (SLR) to analyse the effects of currently available biologic disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi) on the classically accepted poor prognostic factors of RA. All randomized controlled trials reporting subgroup analyses about effects on prognostic factors were identified and synthesized. In a second phase, a two-round Delphi survey was carried out to contrast the SLR results with the grade of agreement of a large group of rheumatologists about the effectiveness of each drug class on each prognostic factor. According to the Delphi results, the only prognostic factor that significantly influenced the selection of treatment was the presence of interstitial lung disease (ILD), being the preferred treatment in this scenario abatacept or rituximab. The rest of the poor prognostic factors (including high disease activity at baseline, disability as measured by the Health Assessment Questionnaire index, seropositivity, elevated acute-phase reactants, and evidence of erosions based on plain radiography or ultrasonography) did not seem to significantly influence rheumatologists when choosing a treatment. The results of the SLR results did not show solid evidence regarding the use of any specific therapy in the management of patients with specific poor factors, except in the case of RA-ILD, although the data in the literature in this regard are not free of bias. The only prognostic factor that seems to significantly influence the selection of treatment is the presence of RA-ILD.
YR 2021
FD 2021-03-06
LK https://hdl.handle.net/10668/25036
UL https://hdl.handle.net/10668/25036
LA en
DS RISalud
RD Apr 11, 2025