RT Journal Article
T1 A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study.
A1 Villasanta-Gonzalez, Alejandro
A1 Alcala-Diaz, Juan Francisco
A1 Vals-Delgado, Cristina
A1 Arenas, Antonio Pablo
A1 Cardelo, Magdalena P
A1 Romero-Cabrera, Juan Luis
A1 Rodriguez-Cantalejo, Fernando
A1 Delgado-Lista, Javier
A1 Malagon, Maria M
A1 Perez-Martinez, Pablo
A1 Schulze, Matthias B
A1 Camargo, Antonio
A1 Lopez-Miranda, Jose
K1 COX
K1 Disease prediction
K1 FA Score
K1 Fatty acids
K1 Type 2 diabetes
AB The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM development. We included 462 coronary heart disease patients from the CORDIOPREV study without T2DM at baseline. Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months. We performed a random classification of patients in a training set, used to build a FA Score, and a Validation set, in which we tested the FA Score. FA selection with the highest prediction power was performed by random survival forest in the Training set, which yielded 4 out of the 24 FA: myristic, petroselinic, α-linolenic and arachidonic acids. We built a FA Score with the selected FA and observed that patients with a higher score presented a greater risk of T2DM development, with an HR of 3.15 (95% CI 2.04-3.37) in the Training set, and an HR of 2.14 (95% CI 1.50-2.84) in the Validation set, per standard deviation (SD) increase. Moreover, patients with a higher FA Score presented lower insulin sensitivity and higher hepatic insulin resistance (p  Our results suggest that a detrimental FA plasma profile precedes the development of T2DM in patients with coronary heart disease, and that this FA profile can, therefore, be used as a predictive biomarker. 
PB Springer
YR 2021
FD 2021-06-24
LK http://hdl.handle.net/10668/19864
UL http://hdl.handle.net/10668/19864
LA en
NO Villasanta-Gonzalez A, Alcala-Diaz JF, Vals-Delgado C, Arenas AP, Cardelo MP, Romero-Cabrera JL, et al.  A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study. Eur J Nutr. 2022 Mar;61(2):843-857
DS RISalud
RD Apr 11, 2025