RT Journal Article
T1 The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
A1 Tristán-Ramos, Pablo
A1 Rubio-Roldan, Alejandro
A1 Peris, Guillermo
A1 Sánchez, Laura
A1 Amador-Cubero, Suyapa
A1 Viollet, Sebastien
A1 Cristofari, Gael
A1 Heras, Sara R.
K1 Lung neoplasms
K1 Carcinoma, squamous cell
K1 Genes, tumor suppressor
K1 MicroRNAs
K1 Neoplasias pulmonares
K1 Carcinoma de células escamosas
K1 Genes Supresores de Tumor
K1 MicroARNs
AB Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect tumor malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition.
PB Springer Nature
YR 2020
FD 2020-11-11
LK http://hdl.handle.net/10668/3782
UL http://hdl.handle.net/10668/3782
LA en
NO Tristán-Ramos P, Rubio-Roldan A, Peris G, Sánchez L, Amador-Cubero S, Viollet S, et al. The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition. Nat Commun. 2020 Nov 11;11(1):5712
DS RISalud
RD Apr 19, 2025