RT Journal Article
T1 Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study.
A1 Papandreou, Christopher
A1 Hernández-Alonso, Pablo
A1 Bulló, Mònica
A1 Ruiz-Canela, Miguel
A1 Yu, Edward
A1 Guasch-Ferré, Marta
A1 Toledo, Estefanía
A1 Dennis, Courtney
A1 Deik, Amy
A1 Clish, Clary
A1 Razquin, Cristina
A1 Corella, Dolores
A1 Estruch, Ramon
A1 Ros, Emilio
A1 Fitó, Montserrat
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Lapetra, José
A1 Ruano, Cristina
A1 Liang, Liming
A1 Martínez-González, Miguel A
A1 Hu, Frank B
A1 Salas-Salvadó, Jordi
K1 PREDIMED
K1 caffeine
K1 coffee
K1 metabolomics
K1 plasma
AB Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (≥50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.
YR 2019
FD 2019-05-08
LK http://hdl.handle.net/10668/13930
UL http://hdl.handle.net/10668/13930
LA en
DS RISalud
RD Apr 12, 2025