RT Journal Article
T1 Pure laparoscopic major liver resection after yttrium90 radioembolization: a case-matched series analysis of feasibility and outcomes.
A1 Aliseda, Daniel
A1 Marti-Cruchaga, Pablo
A1 Zozaya, Gabriel
A1 Benito, Alberto
A1 Lopez-Olaondo, Luis
A1 Rodriguez-Fraile, Macarena
A1 Bilbao, Jose I
A1 Hidalgo, Francisco
A1 Iñarrairaegui, Mercedes
A1 Ciria, Ruben
A1 Pardo, Fernando
A1 Sangro, Bruno
A1 Rotellar, Fernando
K1 Colorectal liver metastases
K1 Hepatocellular carcinoma
K1 Intrahepatic cholangiocarcinoma
K1 Laparoscopic liver resection
K1 Radioembolization
AB Liver surgery after radioembolization (RE) entails highly demanding and challenging procedures due to the frequent combination of large tumors, severe RE-related adhesions, and the necessity of conducting major hepatectomies. Laparoscopic liver resection (LLR) and its associated advantages could provide benefits, as yet unreported, to these patients. The current study evaluated feasibility, morbidity, mortality, and survival outcomes for major laparoscopic liver resection after radioembolization. In this retrospective, single-center study patients diagnosed with hepatocellular carcinoma, intrahepatic cholangiocarcinoma or metastases from colorectal cancer undergoing major laparoscopic hepatectomy after RE were identified from institutional databases. They were matched (1:2) on several pre-operative characteristics to a group of patients that underwent major LLR for the same malignancies during the same period but without previous RE. From March 2011 to November 2020, 9 patients underwent a major LLR after RE. No differences were observed in intraoperative blood loss (50 vs. 150 ml; p = 0.621), operative time (478 vs. 407 min; p = 0.135) or pedicle clamping time (90.5 vs 74 min; p = 0.133) between the post-RE LLR and the matched group. Similarly, no differences were observed on hospital stay (median 3 vs. 4 days; p = 0.300), Clavien-Dindo ≥ III complications (2 vs. 1 cases; p = 0.250), specific liver morbidity (1 vs. 1 case p = 1.000), or 90 day mortality (0 vs. 0; p = 1.000). The laparoscopic approach for post radioembolization patients may be a feasible and safe procedure with excellent surgical and oncological outcomes and meets the current standards for laparoscopic liver resections. Further studies with larger series are needed to confirm the results herein presented.
PB Springer
YR 2022
FD 2022-02-15
LK http://hdl.handle.net/10668/20052
UL http://hdl.handle.net/10668/20052
LA en
NO Aliseda D, Martí-Cruchaga P, Zozaya G, Benito A, Lopez-Olaondo L, Rodríguez-Fraile M, et al. Pure laparoscopic major liver resection after yttrium90 radioembolization: a case-matched series analysis of feasibility and outcomes. Langenbecks Arch Surg. 2022 May;407(3):1099-1111
DS RISalud
RD Apr 8, 2025