RT Journal Article
T1 (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis.
A1 Beitia, Maider
A1 Solano-Iturri, Jon Danel
A1 Errarte, Peio
A1 Calvete-Candenas, Julio
A1 Loizate, Alberto
A1 Etxezarraga, Mari Carmen
A1 Sanz, Begoña
A1 Larrinaga, Gorka
K1 (pro)renin receptor
K1 Wnt
K1 adenoma
K1 angiotensin
K1 biomarkers
K1 colorectal cancer
K1 vATPase
AB (Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling. Its biological role has recently been related to cancer progression and in this study, we investigated its relevance in colorectal cancer (CRC). To that end, we analysed the immunohistochemical expression of PRR in adenomatous polyps and CRCs from the same patients (n = 42), and in primary tumours and nodal and liver metastases from advanced CRC patients (n = 294). In addition, the soluble fraction of PRR was measured by ELISA in plasma samples from 161 CRC patients. The results showed that PRR expression was gradually augmented along the uninvolved mucosa-adenoma-adenocarcinoma sequence. Besides, the stronger expression of PRR in primary tumours was markedly associated with local tumour extent and the onset of metastases. Moreover, PRR expression in both primary and distant metastases was associated with worse 5- and 10-year survival of CRC patients. Plasmatic PRR levels did not change with respect to controls and were not associated with CRC aggressiveness. These results suggest a key role of PRR in the development and progression of CRC and a potential use of this protein as a new prognostic biomarker and/or therapeutic target for this disease.
SN 2072-6694
YR 2019
FD 2019-06-24
LK http://hdl.handle.net/10668/14174
UL http://hdl.handle.net/10668/14174
LA en
DS RISalud
RD Oct 24, 2025