RT Journal Article
T1 Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.
A1 Pardo, María
A1 Crujeiras, Ana B
A1 Amil, María
A1 Agüera, Zaida
A1 Jiménez-Murcia, Susana
A1 Baños, Rosa
A1 Botella, Cristina
A1 Torre, Rafael de la
A1 Estivill, Xavier
A1 Fagundo, Ana B
A1 Fernández-Real, José M
A1 Fernández-García, José C
A1 Fruhbeck, Gema
A1 Gómez-Ambrosi, Javier
A1 Rodríguez, Roser
A1 Tinahones, Francisco J
A1 Fernández-Aranda, Fernando
A1 Casanueva, Felipe F
K1 Fibronectinas
K1 Ghrelina
K1 Índice de masa corporal
K1 Actividad motora
K1 Trastornos de las proteínas sanguíneas
K1 Metabolismo energético
K1 Anorexia nerviosa
K1 Obesidad
AB FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
PB Hindawi Publishing Corporation
SN 1687-8337
YR 2014
FD 2014-04-22
LK http://hdl.handle.net/10668/1846
UL http://hdl.handle.net/10668/1846
LA en
NO Pardo M, Crujeiras AB, Amil M, Agüera Z, Jiménez-Murcia S, Baños R, et al. Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol; 2014:857270
NO Journal Article;
DS RISalud
RD Apr 5, 2025