RT Journal Article
T1 Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study.
A1 Merritt, Melissa A
A1 Riboli, Elio
A1 Murphy, Neil
A1 Kadi, Mai
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Overvad, Kim
A1 Dossus, Laure
A1 Dartois, Laureen
A1 Clavel-Chapelon, Françoise
A1 Fortner, Renée T
A1 Katzke, Verena A
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Trichopoulos, Dimitrios
A1 Palli, Domenico
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H Bas
A1 Peeters, Petra H
A1 Lund, Eiliv
A1 Nakamura, Aurelie
A1 Weiderpass, Elisabete
A1 Quirós, J Ramón
A1 Agudo, Antonio
A1 Molina-Montes, Esther
A1 Larrañaga, Nerea
A1 Dorronsoro, Miren
A1 Cirera, Lluís
A1 Barricarte, Aurelio
A1 Olsson, Åsa
A1 Butt, Salma
A1 Idahl, Annika
A1 Lundin, Eva
A1 Wareham, Nicholas J
A1 Key, Timothy J
A1 Brennan, Paul
A1 Ferrari, Pietro
A1 Wark, Petra A
A1 Norat, Teresa
A1 Cross, Amanda J
A1 Gunter, Marc J
K1 Age at menarche
K1 Age at menopause
K1 Breastfeeding
K1 Mortality
K1 Oral contraceptives
K1 Parity
K1 Lactancia Materna
K1 Estudios de Cohortes
K1 Anticonceptivos Orales
K1 Parto Obstétrico
K1 Menarquia
K1 Neoplasias
K1 Parto
K1 Embarazo
K1 Estudios Prospectivos
K1 Reproducción
AB BACKGROUNDReproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk.METHODSThe analysis was performed within the European Investigation into Cancer and Nutrition prospective cohort study, which enrolled >500,000 women and men from 1992 to 2000, who were residing in a given town/geographic area in 10 European countries. The current analysis included 322,972 eligible women aged 25-70 years with 99 % complete follow-up for vital status. We assessed reproductive characteristics reported at the study baseline including parity, age at the first birth, breastfeeding, infertility, oral contraceptive use, age at menarche and menopause, total ovulatory years, and history of oophorectomy/hysterectomy. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality were determined using Cox proportional hazards regression models adjusted for menopausal status, body mass index, physical activity, education level, and smoking status/intensity and duration.RESULTSDuring a mean follow-up of 12.9 years, 14,383 deaths occurred. The HR (95 % CI) for risk of all-cause mortality was lower in parous versus nulliparous women (0.80; 0.76-0.84), in women who had ever versus never breastfed (0.92; 0.87-0.97), in ever versus never users of oral contraceptives (among non-smokers; 0.90; 0.86-0.95), and in women reporting a later age at menarche (≥15 years versus <12; 0.90; 0.85-0.96; P for trend = 0.038).CONCLUSIONSChildbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated with better health outcomes. These findings may contribute to the development of improved strategies to promote better long-term health in women.
PB BioMed Central
YR 2015
FD 2015-10-30
LK http://hdl.handle.net/10668/2278
UL http://hdl.handle.net/10668/2278
LA en
NO Merritt MA, Riboli E, Murphy N, Kadi M, Tjønneland A, Olsen A, et al. Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study. BMC Med 2015; 13:252
NO Journal Article;
DS RISalud
RD Apr 12, 2025