RT Journal Article
T1 Persistently elevated exhaled nitric oxide fraction is associated with increased risk of exacerbation in COPD
A1 Alcazar-Navarrete, Bernardino
A1 Ruiz Rodriguez, Oliverio
A1 Conde Baena, Pablo
A1 Romero Palacios, Pedro Jose
A1 Agusti, Alvar
K1 Obstructive pulmonary-disease
K1 Eosinophilic airway inflammation
K1 Blood eosinophils
K1 Overlap syndrome
K1 Asthma
K1 Mortality
K1 Life
AB Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO (R), Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO >= 20 ppb.FeNO was = 20 ppb.FeNO was = 20 ppb in clinically stable COPD outpatients are associated with a significantly higher risk of AECOPD.
PB European respiratory soc journals ltd
SN 0903-1936
YR 2018
FD 2018-01-01
LK http://hdl.handle.net/10668/19116
UL http://hdl.handle.net/10668/19116
LA en
DS RISalud
RD Jul 29, 2025