RT Journal Article T1 Persistently elevated exhaled nitric oxide fraction is associated with increased risk of exacerbation in COPD A1 Alcazar-Navarrete, Bernardino A1 Ruiz Rodriguez, Oliverio A1 Conde Baena, Pablo A1 Romero Palacios, Pedro Jose A1 Agusti, Alvar K1 Obstructive pulmonary-disease K1 Eosinophilic airway inflammation K1 Blood eosinophils K1 Overlap syndrome K1 Asthma K1 Mortality K1 Life AB Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO (R), Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO >= 20 ppb.FeNO was = 20 ppb.FeNO was = 20 ppb in clinically stable COPD outpatients are associated with a significantly higher risk of AECOPD. PB European respiratory soc journals ltd SN 0903-1936 YR 2018 FD 2018-01-01 LK http://hdl.handle.net/10668/19116 UL http://hdl.handle.net/10668/19116 LA en DS RISalud RD Jul 4, 2025