%0 Journal Article
%A Alcazar-Navarrete, Bernardino
%A Ruiz Rodriguez, Oliverio
%A Conde Baena, Pablo
%A Romero Palacios, Pedro Jose
%A Agusti, Alvar
%T Persistently elevated exhaled nitric oxide fraction is associated with increased risk of exacerbation in COPD
%D 2018
%@ 0903-1936
%U http://hdl.handle.net/10668/19116
%X Preventing the occurrence of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a major therapeutic goal. We hypothesise that persistently increased levels of exhaled nitric oxide (FeNO) during follow-up can identify a group of COPD patients at higher risk of AECOPD.To test this hypothesis, we measured FeNO levels (HypAir FeNO (R), Medisoft; Sorinnes, Belgium) prospectively in 226 clinically stable COPD outpatients at recruitment and during follow-up (at 6 and 12 months). Patients were stratified according to the number of visits with FeNO >= 20 ppb.FeNO was = 20 ppb.FeNO was = 20 ppb in clinically stable COPD outpatients are associated with a significantly higher risk of AECOPD.
%K Obstructive pulmonary-disease
%K Eosinophilic airway inflammation
%K Blood eosinophils
%K Overlap syndrome
%K Asthma
%K Mortality
%K Life
%~