RT Journal Article T1 Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. A1 Lopez-Moreno, Javier A1 Quintana-Navarro, Gracia M A1 Delgado-Lista, Javier A1 Garcia-Rios, Antonio A1 Delgado-Casado, Nieves A1 Camargo, Antonio A1 Perez-Martinez, Pablo A1 Striker, Gary E A1 Tinahones, Francisco J A1 Perez-Jimenez, Francisco A1 Lopez-Miranda, Jose A1 Yubero-Serrano, Elena M K1 Aged K1 Antioxidants K1 Diet, mediterranean AB A growing body of evidence indicates thatoxidative stress and chronic inflammation are primary riskfactors underlying the aging process and age-relatedFigure 1. Overlap of frailty, disability, comorbidity, and poorself-rated health diseases. 1,2 Addressing these mechanisms could have impli-cations for aging and lead to new therapeutic approachesto these conditions. Advanced glycation end products (AGEs), compoundsderived from glycation of proteins and lipids as result ofthe Maillard reaction, are generated in vivo as a normalconsequence of metabolism. PB Wiley YR 2016 FD 2016 LK http://hdl.handle.net/10668/10010 UL http://hdl.handle.net/10668/10010 LA en NO Lopez-Moreno J, Quintana-Navarro GM, Delgado-Lista J, Garcia-Rios A, Delgado-Casado N, Camargo A, ett al. Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. J Am Geriatr Soc. 2016 Apr;64(4):901-4 NO Supported in part by research grants from the Ministerio de Ciencia e Innovacion (AGL2004–07907, AGL2006–01979, AGL2009–12270), Ministerio de Ciencia y Competitividad (AGL2012–39615) to JL-M; FIS PI10/01041 to P P-M; FIS PI13/00023 to J D-L, Consejeria de Inno-vacion, Ciencia y Empresa, Junta de Andalucıa (P06-CTS-01425 and PI0193/09 to JL-M, PI-0252/09 to J D-L, PI-0058/10 to P P-M), Proyecto de Excelencia, Consejerıa deEconomıa, Innovacion, Ciencia y Empleo (CVI-7450 to JL-M); Merck Serono and Fundacion 2000 (Clinicalresearch in Cardiometabolic to P P-M). The CIBEROBN isan initiative of the Instituto de Salud Carlos III, Madrid,Spain DS RISalud RD Jul 6, 2025