RT Generic
T1 TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease.
A1 Falcon, Debora
A1 Galeano-Otero, Isabel
A1 Martin-Bornez, Marta
A1 Fernandez-Velasco, Maria
A1 Gallardo-Castillo, Isabel
A1 Rosado, Juan A
A1 Ordoñez, Antonio
A1 Smani, Tarik
K1 Ca2+ entry
K1 TRPC channel
K1 cardiac infarction
K1 cardiac repair
AB Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate with other membrane receptors and ion channels to regulate intracellular calcium concentration. Dysfunctions of TRPC channels are involved in many types of cardiovascular diseases. Significant increase in the expression of different TRPC isoforms was observed in different animal models of heart infarcts and in vitro experimental models of ischemia and reperfusion. TRPC channel-mediated increase of the intracellular Ca2+ concentration seems to be required for the activation of the signaling pathway that plays minor roles in the healthy heart, but they are more relevant for cardiac responses to ischemia, such as the activation of different factors of transcription and cardiac hypertrophy, fibrosis, and angiogenesis. In this review, we highlight the current knowledge regarding TRPC implication in different cellular processes related to ischemia and reperfusion and to heart infarction.
PB MDPI AG
YR 2020
FD 2020-01-10
LK http://hdl.handle.net/10668/14954
UL http://hdl.handle.net/10668/14954
LA en
NO Falcón D, Galeano-Otero I, Martín-Bórnez M, Fernández-Velasco M, Gallardo-Castillo I, Rosado JA, et al. TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease. Cells. 2020 Jan 10;9(1):173.
DS RISalud
RD Aug 13, 2025