TY - JOUR AU - Guerrero, Fatima AU - Carmona, Andres AU - Jimenez, Maria Jose AU - Obrero, Teresa AU - Pulido, Victoria AU - Moreno, Juan Antonio AU - Soriano, Sagrario AU - Martín-Malo, Alejandro AU - Aljama, Pedro PY - 2021 DO - 10.3390/toxins13100738 UR - http://hdl.handle.net/10668/3806 T2 - Toxins AB - Endothelial aging may be induced early in pathological situations. The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased... LA - en PB - MDPI KW - Aging KW - Indoxyl sulfate KW - P-cresol KW - Endothelial cells KW - Endothelial dysfunction KW - Senescence KW - Envejecimiento KW - Células endoteliales KW - Senescencia KW - Indicán KW - Hidroxitolueno butilado KW - Tóxinas urémicas KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Cresols KW - Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Endothelium, Vascular KW - Medical Subject Headings::Anatomy::Cells::Epithelial Cells::Endothelial Cells::Human Umbilical Vein Endothelial Cells KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Indican KW - Medical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species KW - Medical Subject Headings::Anatomy::Cells::Epithelial Cells::Endothelial Cells::Human Umbilical Vein Endothelial Cells KW - Medical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic KW - Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic TI - Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins TY - research article ER -