RT Generic
T1 New aspects in celiac disease
A1 Torres, MI
A1 López Casado, MA
A1 Ríos, A
K1 Enfermedad Celíaca
K1 Citocinas
K1 Europa (Continente)  /epidemiología
K1 Antígenos HLA
K1 Antígenos de Histocompatibilidad Clase I
K1 Humanos
K1 Tolerancia Inmunológica
K1 Prevalencia
K1 Estados Unidos/epidemiología
K1 Celiac disease
K1 Oral tolerance
K1 IL-10
K1 TGF-beta
K1 Gluten intolerance
AB Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA-DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.
PB Baishideng Publishing Group Co. Limited
SN 1007-9327
YR 2007
FD 2007-02-28
LK http://hdl.handle.net/10668/577
UL http://hdl.handle.net/10668/577
LA en
NO Torres MI, López Casado Ma, Ríos A. New aspects in celiac disease.World J Gastroenterol. 2007 Feb 28;13(8):1156-61
NO Editorial; Review;
DS RISalud
RD Apr 7, 2025