RT Journal Article
T1 Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery.
T2 Ensayo clínico aleatorizado, controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del ácido tranexámico tópico en el ahorro de pérdidas sanguíneas en pacientes tratados mediante cirugía protésica de rodilla.
A1 Oliva-Moya, F
A1 Belloso-Moreno, I
A1 Vilches-Fernández, J M
A1 Casas-Ruiz, M
A1 Andrés-García, J A
K1 Arthroplasty
K1 Artroplastia
K1 Knee replacement
K1 Prótesis rodilla
K1 Tranexamic acid
K1 Tranexamic topic
K1 Tranexámico tópico
K1 Ácido tranexámico
AB Knee arthroplasty is a major surgery with potential significant blood loss. Assess the efficacy and safety of topical administration of 3g of tranexamic acid (TXA) in terms of reducing blood loss in knee arthroplasty. A randomized, phase III, double-blind, placebo-controlled clinical trial has been conducted. We included 150 patients in 2parallel treatment groups (75 per arm). The solution was administered topically intra-articular after cementation and prior to capsular closure. Analytical determinations were made before and after surgery to quantify blood loss. Total blood loss for the placebo group was 831.5ml and 662.3ml for the TXA group. The difference between the 2groups was 169.2ml; which means a save of 20.4 per cent; this difference being statistically significant (P The administration of TXA topically after cementation of the prosthetic components in total knee arthroplasty in a single dose has demonstrated being safe and effective.
YR 2022
FD 2022-04-20
LK http://hdl.handle.net/10668/22491
UL http://hdl.handle.net/10668/22491
LA en
LA es
DS RISalud
RD Apr 7, 2025