RT Journal Article
T1 Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis.
A1 Rodriguez-Gonzalez, Moises
A1 Perez-Reviriego, Alvaro Antonio
A1 Castellano-Martinez, Ana
A1 Lubian-Lopez, Simon
A1 Benavente-Fernandez, Isabel
K1 NT-proBNP
K1 Tei index
K1 Biomarkers
K1 Echocardiography
K1 Infants
AB To investigate whether the presence of left ventricular myocardial dysfunction (LVMD) assessed by Tei index (LVTX) impacts the outcomes of healthy infants with Respiratory Syncytial Virus Bronchiolitis (RSVB). To explore whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) increases the accuracy of traditional clinical markers in predicting the outcomes. A single-centre, prospective, cohort study including healthy infants aged 1-12 months old admitted for RSVB between 1 October 2016 and 1 April 2017. All patients underwent clinical, laboratory and echocardiographic evaluation within 24 h of admission. Paediatric intensive care unit (PICU) admission was defined as severe disease. We enrolled 50 cases of RSVB (median age of 2 (1-6.5) months; 40% female) and 50 age-matched controls. We observed higher values of LVTX in infants with RSVB than in controls (0.42 vs. 0.36; p = 0.008). Up to nine (18%) children presented with LVMD (LVTX > 0.5), with a higher incidence of PICU admission (89% vs. 5%; p  0.5), with a higher incidence of PICU admission (89% vs. 5%; p  LVMD could be present in healthy infants with RSVB who develop severe disease. NT-proBNP seems to improve traditional clinical markers for outcomes.
PB MDPI
SN 2075-4418
YR 2019
FD 2019-07-26
LK http://hdl.handle.net/10668/14328
UL http://hdl.handle.net/10668/14328
LA en
NO Rodriguez-Gonzalez M, Perez-Reviriego AA, Castellano-Martinez A, Lubian-Lopez S, Benavente-Fernandez I. Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis. Diagnostics (Basel). 2019 Jul 27;9(3):85
DS RISalud
RD Apr 19, 2025