%0 Journal Article
%A Santos García, D
%A De Deus Fonticoba, T
%A Paz González, J M
%A Cores Bartolomé, C
%A Valdés Aymerich, L
%A Muñoz Enríquez, J G
%A Suárez, E
%A Jesús, S
%A Aguilar, M
%A Pastor, P
%A Planellas, L L
%A Cosgaya, M
%A García Caldentey, J
%A Caballol, N
%A Legarda, I
%A Hernández Vara, J
%A Cabo, I
%A López Manzanares, L
%A González Aramburu, I
%A Ávila Rivera, M A
%A Catalán, M J
%A Nogueira, V
%A Puente, V
%A García Moreno, J M
%A Borrué, C
%A Solano Vila, B
%A Álvarez Sauco, M
%A Vela, L
%A Escalante, S
%A Cubo, E
%A Carrillo Padilla, F
%A Martínez Castrillo, J C
%A Sánchez Alonso, P
%A Alonso Losada, M G
%A López Ariztegui, N
%A Gastón, I
%A Kulisevsky, J
%A Blázquez Estrada, M
%A Seijo, M
%A Rúiz Martínez, J
%A Valero, C
%A Kurtis, M
%A de Fábregues, O
%A González Ardura, J
%A Ordás, C
%A López Díaz, L
%A Mir, P
%A Martinez-Martin, P
%A Coppadis Study Group,
%T Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
%D 2021
%@ 2090-8083
%U https://hdl.handle.net/10668/27762
%X In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p  The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.
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