RT Journal Article
T1 Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis.
A1 Cobo-Dols, Manuel
A1 Beato-Zambrano, Carmen
A1 Cabezon-Gutierrez, Luis
A1 Chicas-Sett, Rodolfo
A1 Blancas-Lopez-Barajas, Maria Isabel
A1 Garcia-Navalon, Francisco
A1 Firvida-Perez, Jose Luis
A1 Serrano-Bermudez, Gala
A1 Togores-Torres, Pilar
A1 Delgado-Mingorance, Ignacio
A1 Giraldo-Marin, Alexandra
A1 Libran-Oriol, Anna
A1 Paredes-Lario, Alfredo
A1 Sanchez-Mauriño, Pedro
A1 Higuera-Gomez, Oliver
A1 Moreno-Muñoz, Diana
A1 Jimenez-Lopez, Antonio Javier
A1 Huerta-Gonzalez, Ibone
A1 Sanz-Yague, Almudena
A1 Soler-Lopez, Begoña
K1 Cancer
K1 Constipation
K1 Pain
K1 Quality of life
AB Opioid-induced constipation (OIC) can affect up to 63% of all patients with cancer. The objectives of this study were to assess quality of life as well as efficacy and safety of naloxegol, in patients with cancer with OIC. An observational study was made of a cohort of patients with cancer and with OIC exhibiting an inadequate response to laxatives and treated with naloxegol. The sample consisted of adult outpatients with a Karnofsky performance status score ≥50. The Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) and the Patient Assessment of Constipation Symptoms (PAC-SYM) were applied for 3 months. A total of 126 patients (58.2% males) with a mean age of 61.3 years (range 34-89) were included. Clinically relevant improvements (>0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p Clinically relevant improvements in OIC-related quality of life, number of bowel movements and constipation-related symptoms were recorded as early as after 15 days of treatment with naloxegol in patients with cancer and OIC, with a good safety profile.
PB BMJ Group
YR 2020
FD 2020-05-06
LK http://hdl.handle.net/10668/15521
UL http://hdl.handle.net/10668/15521
LA en
NO Cobo Dols M, Beato Zambrano C, Cabezón Gutiérrez L, Chicas Sett R, Blancas López-Barajas MI, García Navalón F, et al. Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis. BMJ Support Palliat Care. 2021 Mar;11(1):25-31
DS RISalud
RD Apr 6, 2025