RT Journal Article
T1 Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.
A1 Teruel, María
A1 Simeon, Carmen P
A1 Broen, Jasper
A1 Vonk, Madelon C
A1 Carreira, Patricia
A1 Camps, Maria Teresa
A1 García-Portales, Rosa
A1 Delgado-Frías, Esmeralda
A1 Gallego, Maria
A1 Espinosa, Gerard
A1 Beretta, Lorenzo
A1 Airó, Paolo
A1 Lunardi, Claudio
A1 Riemekasten, Gabriela
A1 Witte, Torsten
A1 Krieg, Thomas
A1 Kreuter, Alexander
A1 Distler, Jörg H W
A1 Hunzelmann, Nicolas
A1 Koeleman, Bobby P
A1 Voskuyl, Alexandre E
A1 Schuerwegh, Annemie J
A1 González-Gay, Miguel Angel
A1 Radstake, Timothy R D J
A1 Martin, Javier
K1 Ligando CD40
K1 antígenos CD40
K1 Predisposición genética a la enfermedad
K1 Genotipo
K1 Humanos
K1 Polimorfismo de Nucleótido Simple
K1 Esclerodermia sistémica
AB INTRODUCTIONThe aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).METHODSIn total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.RESULTSNo evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.CONCLUSIONSOur results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.
PB BioMed Central
SN 1478-6354
YR 2012
FD 2012-06-25
LK http://hdl.handle.net/10668/1410
UL http://hdl.handle.net/10668/1410
LA en
NO Teruel M, Simeon CP, Broen J, Vonk MC, Carreira P, Camps MT, et al. Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Res. Ther. 2012; 14(3):R154
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025