TY  - JOUR
AU  - Vico-Barranco, Inmaculada
AU  - Arbulo-Echevarria, Mikel M.
AU  - Serrano-García, Isabel
AU  - Pérez-Linaza, Alba
AU  - Miranda-Sayago, José M.
AU  - Miazek, Arkadiusz
AU  - Narbona-Sánchez, Isaac
AU  - Aguado, Enrique
PY  - 2021
DO  - 10.3390/cells10020343
UR  - http://hdl.handle.net/10668/3963
T2  - Cells
AB  - Intracellular signaling through the T cell receptor (TCR) is essential for T cell development and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 kinases, which result in the phosphorylation of tyrosine residues...
LA  - en
PB  - MDPI
KW  - Lck
KW  - LAT
KW  - J.CaM1.6
KW  - TCR
KW  - Signaling
KW  - T cell receptor
KW  - Phosphorylation
KW  - T lymphocytes
KW  - Protein kinase C
KW  - Receptores de antígenos de linfocitos T
KW  - Fosforilación
KW  - Linfocitos T
KW  - Proteína quinasa C
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing
KW  - Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data::Base Sequence
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Blood Coagulation Factors::Calcium
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Enzyme Activation
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::Jurkat Cells
KW  - Medical Subject Headings::Organisms::Viruses::RNA Viruses::Retroviridae::Lentivirus
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::src-Family Kinases::Lymphocyte Specific Protein...
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Regulatory Elements, Transcriptional::Promoter Regions, Genetic
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Protein Kinase C
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Antigen::Receptors, Antigen, T-Cell
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::ZAP-70 Protein-Tyrosine Kinase
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Antigen::Receptors, Antigen, T-Cell::Receptor-CD3 Complex, Antigen, T-Cell
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
TI  - A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling
TY  - research article
ER  -