RT Generic
T1 Management of Pharmacologic Adverse Effects in Advanced Liver Disease.
A1 Garcia-Cortes, Miren
A1 Garcia-Garcia, Alberto
K1 Advanced liver disease
K1 Altered hepatic architecture
K1 Drug interactions
K1 NSAIDs hepatotoxicity
K1 Patient education
AB As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications. However, there are no tests that accurately determine the degree of impairment of liver metabolic function; therefore, general recommendations are established based on the degree of hepatic extraction, degree of hepatic metabolism, and degree of protein binding. Although the hepatic toxicity of some frequently used drugs, such as acetaminophen, is well known, many health care professionals are unaware or not fully aware of the deleterious effects that other drugs can have on patients with advanced liver injury, as is the case for nonsteroidal anti-inflammatory drugs. It is very important to increase awareness among both health care professionals and patients with advanced liver disease to limit the use of inappropriate drugs and prevent drug-induced liver injury.
PB Adis International Ltd.
YR 2022
FD 2022-06
LK http://hdl.handle.net/10668/21630
UL http://hdl.handle.net/10668/21630
LA en
NO García-Cortés M, García-García A. Management of Pharmacologic Adverse Effects in Advanced Liver Disease. Clin Drug Investig. 2022 Jun;42(Suppl 1):33-38.
DS RISalud
RD Oct 25, 2025