RT Journal Article
T1 Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture
A1 Santos-Marcos, Jose A.
A1 Barroso, Alexia
A1 Rangel-Zuñiga, Oriol A.
A1 Perdices-Lopez, Cecilia
A1 Haro, Carmen
A1 Sanchez-Garrido, Miguel A.
A1 Molina-Abril, Helena
A1 Ohlsson, Claes
A1 Perez-Martinez, Pablo
A1 Poutanen, Matti
A1 Lopez-Miranda, Jose
A1 Perez-Jimenez, Francisco
A1 Tena-Sempere, Manuel
A1 Camargo, Antonio
K1 Gut microbiota
K1 Sex steroids
K1 Gender
K1 Metabolism
K1 miRNAs
K1 Microbioma gastrointestinal
K1 Identidad de género
K1 Metabolismo
K1 MicroARNs
AB Aging is associated with a decline in sex hormones, variable between sexes, that has an impact on many different body systems and might contribute to age-related disease progression. We aimed to characterize the sex differences in gut microbiota, and to explore the impact of depletion of gonadal hormones, alone or combined with postnatal overfeeding, in rats. Many of the differences in the gut microbiota between sexes persisted after gonadectomy, but removal of gonadal hormones shaped several gut microbiota features towards a more deleterious profile, the effect being greater in females than in males, mainly when animals were concurrently overfed. Moreover, we identified several intestinal miRNAs as potential mediators of the impact of changes in gut microbiota on host organism physiology. Our study points out that gonadal hormones contribute to defining sex-dependent differences of gut microbiota, and discloses a potential role of gonadal hormones in shaping gut microbiota, as consequence of the interaction between sex and nutrition. Our data suggest that the changes in gut microbiota, observed in conditions of sex hormone decline, as those caused by ageing in men and menopause in women, might exert different effects on the host organism, which are putatively mediated by gut microbiota-intestinal miRNA cross-talk.
PB Impact Journals
YR 2020
FD 2020-10-27
LK http://hdl.handle.net/10668/3981
UL http://hdl.handle.net/10668/3981
LA en
NO Santos-Marcos JA, Barroso A, Rangel-Zuñiga OA, Perdices-Lopez C, Haro C, Sanchez-Garrido MA, et al. Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture. Aging. 2020 Oct 27;12(20):19979-20000
DS RISalud
RD Apr 12, 2025