%0 Journal Article
%A Ibañez-Sanz, Gemma
%A Diez-Villanueva, Anna
%A Alonso, M Henar
%A Rodriguez-Moranta, Francisco
%A Perez-Gomez, Beatriz
%A Bustamante, Mariona
%A Martin, Vicente
%A Llorca, Javier
%A Amiano, Pilar
%A Ardanaz, Eva
%A Tardon, Adonina
%A Jimenez-Moleon, Jose J
%A Peiro, Rosana
%A Alguacil, Juan
%A Navarro, Carmen
%A Guino, Elisabet
%A Binefa, Gemma
%A Fernandez-Navarro, Pablo
%A Espinosa, Anna
%A Davila-Batista, Veronica
%A Molina, Antonio Jose
%A Palazuelos, Camilo
%A Castaño-Vinyals, Gemma
%A Aragones, Nuria
%A Kogevinas, Manolis
%A Pollan, Marina
%A Moreno, Victor
%T Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.
%D 2017
%U http://hdl.handle.net/10668/10901
%X Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
%K Population screening
%K Colorectal cancer
%~