RT Journal Article
T1 Study of the fetal and maternal microbiota in pregnant women with intrauterine growth restriction and its relationship with inflammatory biomarkers: A case-control study protocol (SPIRIT compliant).
A1 Fernandez-Gonzalez, Sergi
A1 Ortiz-Arrabal, Olimpia
A1 Torrecillas, Ariadna
A1 Perez-Cruz, Miriam
A1 Chueca, Natalia
A1 Gomez-Roig, Maria D
A1 Gomez-Llorente, Carolina
K1 fetal growth restriction
K1 gastrointestinal microbiota
K1 inflammatory biomarkers
AB In general terms, fetal growth restriction (FGR) is considered the impossibility of achieving the genetically determined potential size. In the vast majority of cases, it is related to uteroplacental insufficiency. Although its origin remains unknown and causes are only known in 30% of cases, it is believed to be related to an interaction of environmental and genetic factors with either a fetal or maternal origin. One hypothesis is that alterations in the gastrointestinal microbiota composition, and thus alteration in the immune response, could play a role in FGR development. We performed an observational, prospective study in a subpopulation affected with FGR to elucidate the implications of this microbiota on the FGR condition.A total of 63 fetuses with FGR diagnosed in the third trimester as defined by the Delphi consensus, and 63 fetuses with fetal growth appropriate for gestational age will be recruited. Obstetric and nutritional information will be registered by means of specific questionnaires. We will collect maternal fecal samples between 30 to 36 weeks, intrapartum samples (maternal feces, maternal and cord blood) and postpartum samples (meconium and new-born feces at 6 weeks of life). Samples will be analyzed in the Department of Biochemistry and Molecular Biology II, Nutrition and Food Technology Institute of the University of Granada (UGR), for the determination of the gastrointestinal microbiota composition and its relationship with inflammatory biomarkers.This study will contribute to a better understanding of the influence of gastrointestinal microbiota and related inflammatory biomarkers in the development of FGR.Trial registration: NCT04047966. Registered August 7, 2019, during the recruitment stage. Retrospectively registered. Ongoing research.
PB Wolters Kluwer Health
YR 2020
FD 2020-09-13
LK http://hdl.handle.net/10668/16594
UL http://hdl.handle.net/10668/16594
LA en
NO Fernandez-Gonzalez S, Ortiz-Arrabal O, Torrecillas A, Pérez-Cruz M, Chueca N, Gómez-Roig MD, et al. Study of the fetal and maternal microbiota in pregnant women with intrauterine growth restriction and its relationship with inflammatory biomarkers: A case-control study protocol (SPIRIT compliant). Medicine (Baltimore). 2020 Nov 13;99(46):e22722.
DS RISalud
RD Apr 7, 2025