RT Journal Article T1 Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis. A1 Cruz-Gomez, Álvaro J A1 Forero, Lucía A1 Lozano-Soto, Elena A1 Cano-Cano, Fátima A1 Sanmartino, Florencia A1 Rashid-López, Raúl A1 Paz-Expósito, Jsé A1 Gómez Ramirez, Jaime D A1 Espinosa-Rosso, Raúl A1 González-Rosa, Javier J K1 Neurodegeneration K1 Cortical thickness K1 Neurofilament light chain (sNfL) K1 Gray matter atrophy K1 Cognitive performance AB To determine the relative importance of global or regional MRI and blood markers of neurodegeneration and neuroaxonal injury in predicting cognitive performance for recently diagnosed patients with multiple sclerosis (MS). Thirty-five newly diagnosed patients with relapsing-remitting MS (RRMS) and 23 healthy controls (HCs) simultaneously completed a full clinical and neuropsychological assessment, structural brain MRI, and serum neurofilament light chain (sNfL) level test. Linear regression analyses were performed to determine which global or regional measures of gray matter (GM) atrophy and cortical thickness (CT), in combination with sNfL levels and clinical scores, are most strongly related to neuropsychological impairment. Compared with HCs, patients with MS showed bilateral thalamic GM atrophy (left, p = 0.033; right, p = 0.047) and diminished CT, particularly in the right superior and transverse temporal gyri (p = 0.045; p = 0.037). Regional atrophy failed to add predictive variance, whereas anxiety symptoms, sNfL, and global CT were the best predictors (R2 = 0.404; p < 0.001) of cognitive outcomes, with temporal thickness accounting for greater variance in cognitive deficits than global CT. Thalamic GM atrophy and thinning in temporal regions represent a distinctive MRI trait in the early stages of MS. Although sNfL levels alone do not clearly differentiate HCs and patients with RRMS, in combination with global and regional CT, sNfL levels can better explain the presence of underlying cognitive deficits. Hence, cortical thinning and sNfL increases can be considered 2 parallel neurodegenerative markers in the pathogenesis of progression in newly diagnosed patients with MS. PB Neurology SN 2332-7812 YR 2021 FD 2021-08-31 LK https://hdl.handle.net/10668/25264 UL https://hdl.handle.net/10668/25264 LA en NO Cruz-Gomez ÁJ, Forero L, Lozano-Soto E, Cano-Cano F, Sanmartino F, Rashid-López R, et al. Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021;8(6):e1074. Published 2021 Aug 31. NO This work was supported by the European Regional Development Fund and the Spanish Ministry of Science, Innovation and Universities (grant: RTI2018-096951-A-I00) and the Ministry of Economy and Competitiveness (grant: RYC-2015-18467). DS RISalud RD Jul 2, 2025