RT Journal Article
T1 Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition.
A1 Schmidt, Julie A
A1 Huybrechts, Inge
A1 Overvad, Kim
A1 Eriksen, Anne Kirstine
A1 Tjønneland, Anne
A1 Kaaks, Rudolf
A1 Katzke, Verena
A1 Schulze, Matthias B
A1 Pala, Valeria
A1 Sacerdote, Carlotta
A1 Tumino, Rosario
A1 Bueno-de-Mesquita, Bas
A1 Sanchez-Perez, Maria-Jose
A1 Huerta, José M
A1 Barricarte, Aurelio
A1 Amiano, Pilar
A1 Agudo, Antonio
A1 Bjartell, Anders
A1 Stocks, Tanja
A1 Thysell, Elin
A1 Wennberg, Maria
A1 Weiderpass, Elisabete
A1 Travis, Ruth C
A1 Key, Timothy J
A1 Perez-Cornago, Aurora
K1 dietary amino acid intakes
K1 dietary protein intakes
K1 prostate cancer incidence
K1 prostate cancer mortality
K1 tumour subtypes
AB The association between protein intake and prostate cancer risk remains unclear. To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3 =1.14 (95% CI 1.05-1.23); HRQ 4=1.09 (1.01-1.18); HRQ5 =1.10 (1.02-1.19)); similar results were observed for yogurt protein (HRQ3 =1.14 (1.05-1.24); HRQ4 =1.09 (1.01-1.18); HRQ5 =1.12 (1.04-1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes. Considering the weak associations and many tests, the results must be interpreted with caution. This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.
PB John Wiley & Sons Ltd.
YR 2022
FD 2022-09-12
LK http://hdl.handle.net/10668/21396
UL http://hdl.handle.net/10668/21396
LA en
NO Schmidt JA, Huybrechts I, Overvad K, Eriksen AK, Tjønneland A, Kaaks R, et al. Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition. Cancer Med. 2023 Feb;12(4):4725-4738.
DS RISalud
RD Apr 5, 2025