RT Journal Article
T1 Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease
A1 Salas, Antonio
A1 Pardo-Seco, Jacobo
A1 Cebey-Lopez, Miriam
A1 Gomez-Carballa, Alberto
A1 Obando-Pacheco, Pablo
A1 Rivero-Calle, Irene
A1 Curras-Tuala, Maria-Jose
A1 Amigo, Jorge
A1 Gomez-Rial, Jose
A1 Martinon-Torres, Federico
A1 GENDRES Network, 
K1 Wide association
K1 Taste receptors
K1 Fusion protein
K1 Infection
K1 Polymorphisms
K1 Influenza
K1 Bronchiolitis
K1 Expression
K1 Variants
K1 Tlr4
AB Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients infected by RSV that needed hospitalization due to development of severe bronchiolitis. The Iberian sample (IBS) from The 1000 Genomes Project (1000G) was used as control group; all the association results were pseudo-replicated using other 1000G-European controls and Spanish controls. The study points to SNP rs199665292 in the olfactory receptor (OR) gene OR13C5 as the best candidate variant (P-value = 1.16 x 10(-12); OR = 5.56). Genetic variants at HLA genes (HLA-DQA1, HLA-DPB1), and in the mucin 4 gene (MUC4) also emerge as susceptibility candidates. By collapsing rare variants in genes and weighing by pathogenicity, we obtained confirmatory signals of association in the OR gene OR8U1/OR8U8, the taste receptor TAS2R19, and another mucin gene (MUC6). Overall, we identified new predisposition variants and genes related to RSV infection. Of special interest is the association of RSV to olfactory and taste receptors; this finding is in line with recent evidence pointing to their role in viral infectious diseases.
PB Nature portfolio
SN 2045-2322
YR 2017
FD 2017-11-21
LK https://hdl.handle.net/10668/27409
UL https://hdl.handle.net/10668/27409
LA en
DS RISalud
RD Apr 6, 2025