TY - JOUR AU - Salas-Armenteros, Irene AU - Barroso, Sonia I AU - Rondón, Ana G AU - Pérez, Mónica AU - Andújar, Eloisa AU - Luna, Rosa AU - Aguilera, Andrés PY - 2019 DO - 10.1016/j.celrep.2019.07.010 UR - http://hdl.handle.net/10668/14374 T2 - Cell reports AB - THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. Here, we show that human THO interacts with MFAP1 (microfibrillar-associated protein 1), a spliceosome-associated... LA - en KW - MFAP1/SPP381 KW - THO complex KW - alternative splicing KW - genome instability KW - Alternative Splicing KW - Cell Cycle KW - Cell Proliferation KW - Contractile Proteins KW - DNA-Binding Proteins KW - Extracellular Matrix Proteins KW - Gene Expression Regulation KW - Genome, Human KW - Genomic Instability KW - HEK293 Cells KW - HeLa Cells KW - Humans KW - R-Loop Structures KW - RNA Processing, Post-Transcriptional KW - RNA Splicing Factors KW - RNA-Binding Proteins KW - Saccharomyces cerevisiae KW - Saccharomyces cerevisiae Proteins KW - Spliceosomes TI - Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. TY - research article VL - 28 ER -