RT Journal Article
T1 Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma.
A1 Linares-Clemente, Pedro
A1 Aguilar-Morante, Diana
A1 Rodríguez-Prieto, Ismael
A1 Ramírez, Gema
A1 de Torres, Carmen
A1 Santamaría, Vicente
A1 Pascual-Vaca, Diego
A1 Colmenero-Repiso, Ana
A1 Vega, Francisco M
A1 Mora, Jaume
A1 Cabello, Rosa
A1 Márquez, Catalina
A1 Rivas, Eloy
A1 Pardal, Ricardo
K1 angiogenesis
K1 neural crest-derived progenitors
K1 neuroblastoma
K1 smooth muscle actin (SMA)
K1 tumor stroma
AB Pediatric tumors arise upon oncogenic transformation of stem/progenitor cells during embryonic development. Given this scenario, the existence of non-tumorigenic stem cells included within the aberrant tumoral niche, with a potential role in tumor biology, is an intriguing and unstudied possibility. Here, we describe the presence and function of non-tumorigenic neural crest-derived progenitor cells in aggressive neuroblastoma (NB) tumors. These cells differentiate into neural crest typical mesectodermal derivatives, giving rise to tumor stroma and promoting proliferation and tumor aggressiveness. Furthermore, an analysis of gene expression profiles in stage 4/M NB revealed a neural crest stem cell (NCSC) gene signature that was associated to stromal phenotype and high probability of relapse. Thus, this NCSC gene expression signature could be used in prognosis to improve stratification of stage 4/M NB tumors. Our results might facilitate the design of new therapies by targeting NCSCs and their contribution to tumor stroma.
YR 2017
FD 2017-09-21
LK https://hdl.handle.net/10668/25142
UL https://hdl.handle.net/10668/25142
LA en
DS RISalud
RD Apr 8, 2025